The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance

• Published in: Microbiological research Vol. 166; no. 5; pp. 430 - 436
• Main Authors: Younes, Samer, Bahnan, Wael, Dimassi, Hani I., Khalaf, Roy A.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 20.07.2011
• Subjects: Adhesion; Biofilm; Biofilms - growth & development; Candida albicans; Candida albicans - genetics; Candida albicans - metabolism; Candida albicans - pathogenicity; Candida albicans - physiology; candidiasis; Cell Adhesion; Cell Line; cell walls; chitin; endothelial cells; Endothelial Cells - microbiology; Epithelial Cells - microbiology; Filamentation; Fungal Proteins - genetics; Fungal Proteins - metabolism; fungi; Gene Knockout Techniques; host-pathogen relationships; Humans; hydrogen peroxide; Hydrogen Peroxide - toxicity; hyphae; Membrane Proteins - genetics; Membrane Proteins - metabolism; Oxidative Stress; pathogens; stress tolerance; structural proteins; Candida albicans; Biofilm; Filamentation; Adhesion

Candida albicans is an important fungal pathogen of humans that is responsible for the majority of mucosal and systemic candidiasis. The host–pathogen interaction in C. albicans has been the subject of intense investigation as it is the primary step that leads to establishment of infection. Hwp2 is...