Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity

• Published in: The Journal of experimental medicine Vol. 213; no. 11; pp. 2489 - 2501
• Main Authors: Kishi, Yasuhiro, Kondo, Takaaki, Xiao, Sheng, Yosef, Nir, Gaublomme, Jellert, Wu, Chuan, Wang, Chao, Chihara, Norio, Regev, Aviv, Joller, Nicole, Kuchroo, Vijay K.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 17.10.2016
• Subjects: Animals; Cell Differentiation - immunology; Endothelial Protein C Receptor; Gene Expression Profiling; Inflammation - genetics; Inflammation - pathology; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Promoter Regions, Genetic - genetics; Protein Binding; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Interleukin - metabolism; Receptors, Interleukin-1 - metabolism; STAT3 Transcription Factor - metabolism; Th17 Cells - immunology

Th17 cells are key players in defense against pathogens and maintaining tissue homeostasis, but also act as critical drivers of autoimmune diseases. Based on single-cell RNA-seq profiling of pathogenic versus nonpathogenic Th17 cells, we identified protein C receptor (PROCR) as a cell surface molecu...