Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 2; p. 177
• Main Authors: Mercatelli, Daniele, Balboni, Nicola, Palma, Alessandro, Aleo, Emanuela, Sanna, Pietro Paolo, Perini, Giovanni, Giorgi, Federico Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 28.01.2021; MDPI AG
• Subjects: gene networks; master regulator analysis; neuroblastoma; single-cell; transcriptomics; neuroblastoma; single-cell; transcriptomics; master regulator analysis; gene networks

Neuroblastoma (NBL) is a pediatric cancer responsible for more than 15% of cancer deaths in children, with 800 new cases each year in the United States alone. Genomic amplification of the MYC oncogene family member MYCN characterizes a subset of high-risk pediatric neuroblastomas. Several cellular m...