Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site

• Published in: Journal of general virology Vol. 98; no. 6; pp. 1274 - 1281
• Main Authors: Mögling, Ramona, Richard, Mathilde J., Vliet, Stefan van der, Beek, Ruud van, Schrauwen, Eefje J. A., Spronken, Monique I., Rimmelzwaan, Guus F., Fouchier, Ron A. M.
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.06.2017
• Subjects: Animals; Arginine - genetics; Arginine - metabolism; Catalytic Domain; DNA Mutational Analysis; Erythrocytes; Evolution, Molecular; Hemagglutination; Hemagglutination Inhibition Tests; Humans; Influenza A Virus, H3N2 Subtype - enzymology; Influenza A Virus, H3N2 Subtype - genetics; Influenza, Human - virology; Neuraminidase - genetics; Neuraminidase - metabolism; Recombination, Genetic; Reverse Genetics; Turkeys

Over the last decade, an increasing proportion of circulating human influenza A(H3N2) viruses exhibited haemagglutination activity that was sensitive to neuraminidase inhibitors. This change in haemagglutination as compared to older circulating A(H3N2) viruses prompted an investigation of the underl...