Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development

• Published in: Journal of cell science Vol. 130; no. 4; pp. 745 - 753
• Main Authors: Behm, Mikaela, Wahlstedt, Helene, Widmark, Albin, Eriksson, Maria, Öhman, Marie
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.02.2017
• Subjects: Adenosine; Adenosine - metabolism; Adenosine Deaminase - chemistry; Adenosine Deaminase - metabolism; alpha Karyopherins; Animals; Brain; Cell Differentiation - genetics; Cell Nucleus - metabolism; Cells, Cultured; Cerebral Cortex - cytology; Coding; Editing; HEK293 Cells; Humans; Inosine - metabolism; Isoforms; Maturation; Mice; Models, Biological; Neurogenesis - genetics; Neurons; Neurons - metabolism; Neurotransmission; NIMA-Interacting Peptidylprolyl Isomerase - metabolism; Nuclear Localization Signals - metabolism; Nuclear transport; Nuclei; Pin1 protein; Protein Binding; Rats; Ribonucleic acid; RNA; RNA Editing; Substrates; Pin1; Importin-α4; ADAR2; A-to-I RNA editing
• ISSN: 0021-9533; 1477-9137; 1477-9137
• DOI: 10.1242/jcs.200055

Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known sites that are subject to selective RNA editing have been found to result in diversified protein isoforms that are involved in neurotransmission. In the absence of the active editing enzymes ADAR1 or ADAR2...