Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

• Published in: Investigative ophthalmology & visual science Vol. 63; no. 1; p. 24
• Main Authors: Huang, Furong, Shu, Ziheng, Huang, Qin, Chen, Kaijie, Yan, Wenjun, Wu, Wenjing, Yang, Jinglei, Wang, Qiongsi, Wang, Fengjiao, Zhang, Chunlan, Qu, Jia, Zhou, Xiangtian
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 20.01.2022
• Subjects: Animals; Disease Models, Animal; Electroretinography; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myopia - genetics; Myopia - metabolism; Myopia - pathology; Receptors, Dopamine D2 - biosynthesis; Receptors, Dopamine D2 - genetics; Retina - metabolism; Retina - pathology; RNA - genetics; Visual Neuroscience

To learn more about the locations of dopamine D2 receptors (D2Rs) that regulate form-deprivation myopia (FDM), using different transgenic mouse models. One eye of D2R-knockout (KO) mice and wild-type littermates was subjected to four weeks of monocular FDM, whereas the fellow eye served as control....