Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography
To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes. In total, 39 unaffected h...
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Published in | Translational vision science & technology Vol. 10; no. 2; p. 30 |
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The Association for Research in Vision and Ophthalmology
18.02.2021
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Abstract | To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes.
In total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid layer, especially in the center, the inner, or the outer areas centered at the fovea. The values and their association with the demographic data were analyzed. Near-infrared fundus autofluorescence (NIRAF) was also used, in the same manner, for the comparison. Twenty-eight of 39 eyes were measured twice to evaluate intrasession repeatability.
Both the polarimetric entropy in the RPE and the gray level in NIRAF, decreased from the center to the periphery (P < 0.001). The polarimetric entropy in the RPE was significantly associated with age in each area (P ≤ 0.001). In the RPE and the superficial choroid, the polarimetric entropy was negatively associated with axial length in each area (P ≤ 0.002). The intraclass correlation coefficient of the polarimetric entropy in the same session was excellent in each area of the RPE, superficial choroid, or total choroid layer (0.94-0.98).
The distribution of fundus melanin pigment-related depolarization was evaluated using PS-OCT. The depolarization was associated with the subjects' demographic data, such as age or axial length.
The presented information in healthy eyes provides an essential basis for the investigation into a variety of chorioretinal pathologies. |
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AbstractList | To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes.
In total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid layer, especially in the center, the inner, or the outer areas centered at the fovea. The values and their association with the demographic data were analyzed. Near-infrared fundus autofluorescence (NIRAF) was also used, in the same manner, for the comparison. Twenty-eight of 39 eyes were measured twice to evaluate intrasession repeatability.
Both the polarimetric entropy in the RPE and the gray level in NIRAF, decreased from the center to the periphery (P < 0.001). The polarimetric entropy in the RPE was significantly associated with age in each area (P ≤ 0.001). In the RPE and the superficial choroid, the polarimetric entropy was negatively associated with axial length in each area (P ≤ 0.002). The intraclass correlation coefficient of the polarimetric entropy in the same session was excellent in each area of the RPE, superficial choroid, or total choroid layer (0.94-0.98).
The distribution of fundus melanin pigment-related depolarization was evaluated using PS-OCT. The depolarization was associated with the subjects' demographic data, such as age or axial length.
The presented information in healthy eyes provides an essential basis for the investigation into a variety of chorioretinal pathologies. PurposeTo investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes. MethodsIn total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid layer, especially in the center, the inner, or the outer areas centered at the fovea. The values and their association with the demographic data were analyzed. Near-infrared fundus autofluorescence (NIRAF) was also used, in the same manner, for the comparison. Twenty-eight of 39 eyes were measured twice to evaluate intrasession repeatability. ResultsBoth the polarimetric entropy in the RPE and the gray level in NIRAF, decreased from the center to the periphery (P < 0.001). The polarimetric entropy in the RPE was significantly associated with age in each area (P ≤ 0.001). In the RPE and the superficial choroid, the polarimetric entropy was negatively associated with axial length in each area (P ≤ 0.002). The intraclass correlation coefficient of the polarimetric entropy in the same session was excellent in each area of the RPE, superficial choroid, or total choroid layer (0.94-0.98). ConclusionsThe distribution of fundus melanin pigment-related depolarization was evaluated using PS-OCT. The depolarization was associated with the subjects' demographic data, such as age or axial length. Translational RelevanceThe presented information in healthy eyes provides an essential basis for the investigation into a variety of chorioretinal pathologies. |
Author | Fujita, Asahi Inoue, Tatsuya Amari, Tatsuaki Yamanari, Masahiro Sugiyama, Satoshi Aoki, Nobuyori Kato, Satoshi Yamamoto, Motoshi Azuma, Keiko Komatsu, Kayoko Obata, Ryo Aihara, Makoto Ueda, Kohei |
Author_xml | – sequence: 1 givenname: Asahi surname: Fujita fullname: Fujita, Asahi organization: Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan – sequence: 2 givenname: Tatsuaki surname: Amari fullname: Amari, Tatsuaki organization: Eguchi Eye Hospital, Hakodate, Japan – sequence: 3 givenname: Kohei surname: Ueda fullname: Ueda, Kohei organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 4 givenname: Keiko surname: Azuma fullname: Azuma, Keiko organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 5 givenname: Tatsuya surname: Inoue fullname: Inoue, Tatsuya organization: Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan – sequence: 6 givenname: Kayoko surname: Komatsu fullname: Komatsu, Kayoko organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 7 givenname: Motoshi surname: Yamamoto fullname: Yamamoto, Motoshi organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 8 givenname: Nobuyori surname: Aoki fullname: Aoki, Nobuyori organization: Tomey Corporation, Nagoya, Japan – sequence: 9 givenname: Masahiro surname: Yamanari fullname: Yamanari, Masahiro organization: Tomey Corporation, Nagoya, Japan – sequence: 10 givenname: Satoshi surname: Sugiyama fullname: Sugiyama, Satoshi organization: Tomey Corporation, Nagoya, Japan – sequence: 11 givenname: Makoto surname: Aihara fullname: Aihara, Makoto organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 12 givenname: Satoshi surname: Kato fullname: Kato, Satoshi organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan – sequence: 13 givenname: Ryo surname: Obata fullname: Obata, Ryo organization: Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan |
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CitedBy_id | crossref_primary_10_1038_s41598_022_07591_9 crossref_primary_10_1038_s41598_022_07818_9 crossref_primary_10_1038_s41598_022_11192_x crossref_primary_10_1167_iovs_64_14_6 crossref_primary_10_1371_journal_pone_0257000 crossref_primary_10_1371_journal_pone_0278679 |
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