Molecularly imprinted polymers based drug delivery devices: a way to application in modern pharmacotherapy. A review

This review presents the current status of molecularly imprinted polymers (MIPs) for drug delivery, in particular the studies that focus on biocompatibility, cytotoxicity, and in vitro or in vivo behavior of MIPs. It also shows the limitations that hamper the introduction of MIPs to pharmacotherapy...

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Bibliographic Details
Published inMaterials Science & Engineering C Vol. 76; pp. 1344 - 1353
Main Author Lulinski, Piotr
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2017
Elsevier BV
Subjects
Biocompatibility
Commercialization
Construction materials
Cytotoxicity
Delayed-Action Preparations
Devices
Drug delivery
Drug Delivery Systems
Drug therapy
Drugs
Feedback
Imprinted polymers
Imprinting
In vivo methods and tests
Intravenous administration
Materials science
Molecular Imprinting
Molecularly imprinted polymers
Pharmacology
Pharmacotherapy
Polymers
Skin
Sustained/controlled release
Toxicity
Pharmacotherapy
Sustained/controlled release
Molecularly imprinted polymers
Drug delivery
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Summary:This review presents the current status of molecularly imprinted polymers (MIPs) for drug delivery, in particular the studies that focus on biocompatibility, cytotoxicity, and in vitro or in vivo behavior of MIPs. It also shows the limitations that hamper the introduction of MIPs to pharmacotherapy and prevent this class of polymers from commercialization. MIPs are promising materials in the construction of drug delivery devices because they can provide improved delivery profiles or longer release times and deliver the drugs in the feedback regulated way, which is extremely important in modern pharmacotherapy. Here, a brief overview of the imprinting process and a concise description of drug release mechanisms from the imprinted materials will be presented followed by the discussion of potential MIP drug delivery devices for ocular, dermal, intravenous and oral routes of administration. Finally, future prospects for imprinted drug delivery forms will be outlined. [Display omitted] •A review of recent literature of imprinted drug delivery devices is presented•Biocompatibility, cytotoxicity, in vivo behavior of imprinted devices are emphasized•Reasons preventing use of imprinted materials as drug delivery are discussed
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2017.02.138