Role of Adenosine and Nitric Oxide on the Mechanisms of Action of Dipyridamole

• Published in: Stroke (1970) Vol. 36; no. 10; pp. 2170 - 2175
• Main Authors: Gamboa, Alfredo, Abraham, Robert, Diedrich, Andre, Shibao, Cyndya, Paranjape, Sachin Y., Farley, Ginnie, Biaggioni, Italo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.10.2005
• Subjects: Acetylcholine - administration & dosage; Adenosine - chemistry; Adenosine - metabolism; Adenosine - physiology; Adult; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Aspirin - administration & dosage; Biological and medical sciences; Blood Flow Velocity - drug effects; Cardiovascular System - drug effects; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cross-Over Studies; Cyclic GMP - metabolism; Dipyridamole - pharmacology; Dose-Response Relationship, Drug; Double-Blind Method; Fundamental and applied biological sciences. Psychology; General and cellular metabolism. Vitamins; Humans; Medical sciences; Models, Biological; Neurology; Nitric Oxide - chemistry; Nitric Oxide - metabolism; Nitric Oxide - physiology; Nitroprusside - administration & dosage; Pharmacology. Drug treatments; Phosphoric Diester Hydrolases - metabolism; Time Factors; Vascular diseases and vascular malformations of the nervous system; Vasodilator Agents - pharmacology; Vertebrates: nervous system and sense organs; Antianginal agent; Prostaglandin-endoperoxide synthase; Purine nucleoside; Coronary vasodilator agent; Cardiovascular disease; Acetylsalicylic acid; Vascular disease; aspirin; Salicylates; Mechanism of action; Cerebrovascular disease; Regional blood flow; Stroke; Adenosine; Nervous system diseases; Enzyme; Dipyridamole; Enzyme inhibitor; Antiplatelet agent; Cerebral disorder; Endothelium; Non steroidal antiinflammatory agent; Analgesic; Nitric oxide; Central nervous system disease; Antipyretic; Oxidoreductases

Background and Purpose— The combination of dipyridamole and aspirin has been shown to be more effective than aspirin alone in the secondary prevention of stroke. Dipyridamole may act by inhibiting adenosine uptake, thus potentiating its actions. Dipyridamole also inhibits cGMP-specific phosphodieste...