Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

• Published in: Blood Vol. 105; no. 2; pp. 855 - 861
• Main Authors: St. Pierre, Timothy G., Clark, Paul R., Chua-anusorn, Wanida, Fleming, Adam J., Jeffrey, Gary P., Olynyk, John K., Pootrakul, Pensri, Robins, Erin, Lindeman, Robert
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.01.2005; The Americain Society of Hematology
• Subjects: Biological and medical sciences; Biopsy; Chlorides; Humans; Investigative techniques, diagnostic techniques (general aspects); Iron - metabolism; Iron Overload - metabolism; Iron Overload - pathology; Liver - metabolism; Liver - pathology; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Manganese Compounds; Medical sciences; Metabolic diseases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Phantoms, Imaging; Protons; Reproducibility of Results; Sensitivity and Specificity; Human; Overload; Digestive system; Liver; Magnetic resonance; Non invasive method; Proton; Exploration; Medical imagery; Iron

Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of me...