BET Protein-Mediated Transcriptional Regulation in Heart Failure

• Published in: International journal of molecular sciences Vol. 22; no. 11; p. 6059
• Main Authors: Ijaz, Talha, Burke, Michael A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 04.06.2021; MDPI AG
• Subjects: Animals; BET; BRD4; chromatin remodeling; dilated cardiomyopathy; Gene Expression Regulation; heart failure; Heart Failure - genetics; Homeostasis; Humans; Models, Biological; Myocytes, Cardiac - metabolism; phospholamban; Review; Transcription Factors - metabolism; BET; heart failure; transcription regulation; chromatin remodeling; phospholamban; superenhancer; BRD4; dilated cardiomyopathy

Heart failure is a complex disease process with underlying aberrations in neurohormonal systems that promote dysregulated cellular signaling and gene transcription. Over the past 10 years, the advent of small-molecule inhibitors that target transcriptional machinery has demonstrated the importance o...