Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

• Published in: Journal of virology Vol. 94; no. 19
• Main Authors: Vanderheiden, Abigail, Ralfs, Philipp, Chirkova, Tatiana, Upadhyay, Amit A., Zimmerman, Matthew G., Bedoya, Shamika, Aoued, Hadj, Tharp, Gregory M., Pellegrini, Kathryn L., Manfredi, Candela, Sorscher, Eric, Mainou, Bernardo, Lobby, Jenna L., Kohlmeier, Jacob E., Lowen, Anice C., Shi, Pei-Yong, Menachery, Vineet D., Anderson, Larry J., Grakoui, Arash, Bosinger, Steven E., Suthar, Mehul S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.09.2020
• Subjects: Animals; Betacoronavirus - immunology; Betacoronavirus - physiology; Bronchi - cytology; Bronchi - immunology; Bronchi - virology; Cell Line; Cells, Cultured; Cellular Response to Infection; Chemokines - immunology; Chlorocebus aethiops; Coronavirus Infections - immunology; Coronavirus Infections - virology; COVID-19; Cytokines - immunology; Dogs; Epithelial Cells - immunology; Epithelial Cells - virology; Humans; Interferon Lambda; Interferon Type I - immunology; Interferons - immunology; Lung - cytology; Lung - immunology; Lung - virology; Madin Darby Canine Kidney Cells; Pandemics; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; SARS-CoV-2; Vero Cells; Virus Replication; COVID-19; lung; type I interferon; SARS-CoV-2; cytokines; innate immunity

The current pandemic of respiratory illness, COVID-19, is caused by a recently emerged coronavirus named SARS-CoV-2. This virus infects airway and lung cells causing fever, dry cough, and shortness of breath. Severe cases of COVID-19 can result in lung damage, low blood oxygen levels, and even death...