Neutrophil phenotypes and functions in cancer: A consensus statement

• Published in: The Journal of experimental medicine Vol. 219; no. 6
• Main Authors: Quail, Daniela F., Amulic, Borko, Aziz, Monowar, Barnes, Betsy J., Eruslanov, Evgeniy, Fridlender, Zvi G., Goodridge, Helen S., Granot, Zvi, Hidalgo, Andrés, Huttenlocher, Anna, Kaplan, Mariana J., Malanchi, Ilaria, Merghoub, Taha, Meylan, Etienne, Mittal, Vivek, Pittet, Mikael J., Rubio-Ponce, Andrea, Udalova, Irina A., van den Berg, Timo K., Wagner, Denisa D., Wang, Ping, Zychlinsky, Arturo, de Visser, Karin E., Egeblad, Mikala, Kubes, Paul
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.06.2022
• Series: Cancer Focus
• Subjects: Cancer Focus; Humans; Immunity, Innate; Inflammation; Innate immunity and inflammation; Neoplasms - genetics; Neutrophils; Phenotype; Review; Tumor immunology

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however,...