Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however,...
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| Published in | The Journal of experimental medicine Vol. 219; no. 6 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
06.06.2022
|
| Series | Cancer Focus |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. |
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| AbstractList | There is a growing appreciation for the vastness of neutrophil functional states in cancer. Quail et al. provide a consensus statement on mechanisms governing neutrophil heterogeneity in the context of malignancy and discuss controversies and solutions in neutrophil research.
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. |
| Author | Huttenlocher, Anna Kaplan, Mariana J. Aziz, Monowar Malanchi, Ilaria Udalova, Irina A. Granot, Zvi Wagner, Denisa D. Zychlinsky, Arturo Meylan, Etienne Mittal, Vivek Pittet, Mikael J. de Visser, Karin E. Fridlender, Zvi G. Kubes, Paul Eruslanov, Evgeniy Amulic, Borko Hidalgo, Andrés Wang, Ping Merghoub, Taha van den Berg, Timo K. Rubio-Ponce, Andrea Barnes, Betsy J. Quail, Daniela F. Egeblad, Mikala Goodridge, Helen S. |
| AuthorAffiliation | 7 Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel 20 Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Université Libre de Bruxelles, Anderlecht, Belgium 5 Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 21 Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium 13 Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 23 Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 35 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1 Rosalind and Morris Goodman Cancer Institute, Department of Physiology, McGill University, Montreal, Quebec, Canada 38 Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 9 Department of Developmental |
| AuthorAffiliation_xml | – name: 27 AGORA Cancer Research Center, Lausanne, Switzerland – name: 4 Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, NY – name: 19 Weill Cornell Medical College, New York, NY – name: 11 Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain – name: 28 University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK – name: 29 Laboratory of Immunotherapy, Sanquin Research, Amsterdam, Netherlands – name: 21 Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium – name: 6 Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA – name: 8 Board of Governors Regenerative Medicine Institute and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA – name: 35 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY – name: 7 Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel – name: 22 Department of Cardiothoracic Surgery, Neuberger Berman Foundation Lung Cancer Research Center, Weill Cornell Medicine, New York, NY – name: 31 Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA – name: 20 Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Université Libre de Bruxelles, Anderlecht, Belgium – name: 24 Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland – name: 3 Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY – name: 23 Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY – name: 17 Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY – name: 37 Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY – name: 25 Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland – name: 2 Cellular and Molecular Medicine, University of Bristol, Bristol, UK – name: 12 Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI – name: 33 Division of Tumour Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands – name: 36 Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada – name: 9 Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, Jerusalem, Israel – name: 16 Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY – name: 5 Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY – name: 15 Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK – name: 38 Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada – name: 10 Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT – name: 13 Department of Pediatrics, University of Wisconsin-Madison, Madison, WI – name: 14 Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD – name: 18 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY – name: 26 Department of Oncology, Geneva University Hospitals, Geneva, Switzerland – name: 32 Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany – name: 39 Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada – name: 30 Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands – name: 1 Rosalind and Morris Goodman Cancer Institute, Department of Physiology, McGill University, Montreal, Quebec, Canada – name: 34 Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands |
| Author_xml | – sequence: 1 givenname: Daniela F. orcidid: 0000-0002-6969-3250 surname: Quail fullname: Quail, Daniela F. – sequence: 2 givenname: Borko orcidid: 0000-0002-8518-8393 surname: Amulic fullname: Amulic, Borko – sequence: 3 givenname: Monowar orcidid: 0000-0002-8195-4505 surname: Aziz fullname: Aziz, Monowar – sequence: 4 givenname: Betsy J. orcidid: 0000-0001-6766-4352 surname: Barnes fullname: Barnes, Betsy J. – sequence: 5 givenname: Evgeniy orcidid: 0000-0003-0743-5026 surname: Eruslanov fullname: Eruslanov, Evgeniy – sequence: 6 givenname: Zvi G. orcidid: 0000-0002-6122-1988 surname: Fridlender fullname: Fridlender, Zvi G. – sequence: 7 givenname: Helen S. orcidid: 0000-0001-8097-2413 surname: Goodridge fullname: Goodridge, Helen S. – sequence: 8 givenname: Zvi orcidid: 0000-0001-9692-5785 surname: Granot fullname: Granot, Zvi – sequence: 9 givenname: Andrés orcidid: 0000-0001-5513-555X surname: Hidalgo fullname: Hidalgo, Andrés – sequence: 10 givenname: Anna orcidid: 0000-0001-7940-6254 surname: Huttenlocher fullname: Huttenlocher, Anna – sequence: 11 givenname: Mariana J. orcidid: 0000-0003-2968-0815 surname: Kaplan fullname: Kaplan, Mariana J. – sequence: 12 givenname: Ilaria orcidid: 0000-0003-4867-3311 surname: Malanchi fullname: Malanchi, Ilaria – sequence: 13 givenname: Taha orcidid: 0000-0002-1518-5111 surname: Merghoub fullname: Merghoub, Taha – sequence: 14 givenname: Etienne orcidid: 0000-0002-0899-2230 surname: Meylan fullname: Meylan, Etienne – sequence: 15 givenname: Vivek orcidid: 0000-0002-4764-7413 surname: Mittal fullname: Mittal, Vivek – sequence: 16 givenname: Mikael J. orcidid: 0000-0002-2060-4691 surname: Pittet fullname: Pittet, Mikael J. – sequence: 17 givenname: Andrea orcidid: 0000-0002-4275-8835 surname: Rubio-Ponce fullname: Rubio-Ponce, Andrea – sequence: 18 givenname: Irina A. orcidid: 0000-0002-6716-2528 surname: Udalova fullname: Udalova, Irina A. – sequence: 19 givenname: Timo K. orcidid: 0000-0002-2052-3904 surname: van den Berg fullname: van den Berg, Timo K. – sequence: 20 givenname: Denisa D. orcidid: 0000-0002-4494-413X surname: Wagner fullname: Wagner, Denisa D. – sequence: 21 givenname: Ping orcidid: 0000-0002-1557-0394 surname: Wang fullname: Wang, Ping – sequence: 22 givenname: Arturo orcidid: 0000-0001-6018-193X surname: Zychlinsky fullname: Zychlinsky, Arturo – sequence: 23 givenname: Karin E. orcidid: 0000-0002-0293-868X surname: de Visser fullname: de Visser, Karin E. – sequence: 24 givenname: Mikala orcidid: 0000-0002-3371-1445 surname: Egeblad fullname: Egeblad, Mikala – sequence: 25 givenname: Paul orcidid: 0000-0002-2835-4244 surname: Kubes fullname: Kubes, Paul |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35522219$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 T.K. van den Berg’s present address is Byondis BV, Nijmegen, Netherlands. Disclosures: E. Eruslanov reported a patent to the use of HLA-DR+CD32hiCD64hi hybrid neutrophils with characteristics of antigen-presenting cells to augment therapy for cancer or infectious diseases pending. Z.G. Fridlender reported “other” from Immunyx outside the submitted work; in addition, Z.G. Fridlender had a patent to ID - 6494-1 licensed "Immunyx." Z. Granot reported personal fees from Immunyx Pharma outside the submitted work. A. Hidalgo is a paid consultant for Flagship Pioneering, which is not related to this work. M.J. Pittet reported personal fees from AstraZeneca, Debiopharm, Elstar Therapeutics, ImmuneOncia, KSQ Therapeutics, MaxiVax, Merck, Molecular Partners, Third Rock Ventures, and Tidal outside the submitted work; in addition, M.J. Pittet has been a consultant for Aileron Therapeutics, Cygnal Therapeutics, and Siamab Therapeutics. T.K van den Berg is an inventor on patent application WO2009/131453 A1, owned by Sanquin Blood Supply Organization, licensed to Byondis BV, related to the targeting of CD47-SIRPα in cancer. D.D. Wagner reported personal fees from Takeda Pharmaceutical and “other” from Neutrolis, SAB during the conduct of the study. K.E. de Visser reported grants from Roche/Genentech and personal fees from Macomics outside the submitted work. M. Egeblad is a member of the research advisory board for brensocatib for Insmed, Inc, a member of the scientific advisory board for Vividion Therapeutics, Inc., and a consultant for Protalix, Inc outside the submitted work. T. Merghoub is a co-founder and holds equity in IMVAQ Therapeutics. He is a consultant of Immunos Therapeutics, ImmunoGenesis, and Pfizer. In addition, T Merghoub has research support from Bristol-Myers Squibb, Surface Oncology, Kyn Therapeutics, Infinity Pharmaceuticals Inc., Peregrine Pharmaceuticals Inc., Adaptive Biotechnologies, Leap Therapeutics Inc., and Aprea. He has patents on applications related to work on oncolytic viral therapy, α-virus-based vaccine, neo antigen modeling, CD40, GITR, OX40, PD-1, and CTLA-4. No other disclosures were reported. |
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| Snippet | Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of... There is a growing appreciation for the vastness of neutrophil functional states in cancer. Quail et al. provide a consensus statement on mechanisms governing... |
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| SubjectTerms | Cancer Focus Humans Immunity, Innate Inflammation Innate immunity and inflammation Neoplasms - genetics Neutrophils Phenotype Review Tumor immunology |
| Title | Neutrophil phenotypes and functions in cancer: A consensus statement |
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