Alteramide B is a microtubule antagonist of inhibiting Candida albicans - Ding, Yanjiao; Li, Yaoyao; Li, Zhenyu; Zhang, Juanli; Lu, Chunhua; Wang, Haoxin; Shen, Yuemao; Du, Liangcheng (Biochimica et biophysica acta, 2016)
Keywords: Alteramide B; Animals; antagonists; Antifungal Agents - metabolism; Antifungal Agents - pharmacology; Apoptosis; Apoptosis - drug effects; binding sites; Binding Sites - drug effects; Candida albicans; Candida albicans - drug effects; Candida albicans - pathogenicity; Candida albicans SC5314; candidiasis; Candidiasis - drug therapy; Candidiasis - microbiology; cell cycle checkpoints; drugs; flow cytometry; fluorescence; gene overexpression; genes; Humans; Lactams, Macrocyclic - pharmacology; Lead - pharmacology; Lysobacter enzymogenes; mass spectrometry; mechanism of action; Membrane Potential, Mitochondrial - drug effects; Mice; microtubules; Microtubules - drug effects; molecular dynamics; Molecular Dynamics Simulation; molecular models; mutants; mutation; nuclear magnetic resonance spectroscopy; polymerization; Reactive oxygen species; Reactive Oxygen Species - metabolism; transmission electron microscopes; tubulin; Tubulin - metabolism; Tubulin Modulators - chemistry; Tubulin Modulators - pharmacology; yeasts; β-Tubulin; Candida albicans SC5314; Reactive oxygen species; Alteramide B; β-Tubulin; Apoptosis