Anti-Melanogenic Effects of Takifugu flavidus Muscle Hydrolysate in B16F10 Melanoma Cells and Zebrafish

• Published in: Marine drugs Vol. 22; no. 5; p. 206
• Main Authors: Hu, Jinjin, Chen, Bei, Qu, Shuaijie, Liu, Shuji, Yang, Xiaoyu, Qiao, Kun, Su, Yongchang, Liu, Zhihui, Chen, Xiaoe, Liu, Zhiyu, Wang, Qin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2024
• Subjects: alpha-melanocyte-stimulating hormone; Animals; catechol oxidase; Cell Line, Tumor; computational simulation; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Danio rerio; Dopachrome isomerase; Enzymes; Experiments; Freshwater fishes; hydrogen; Hydrogen bonding; Hydrogen bonds; Hydrolysates; Hyperpigmentation; inhibitory mechanism; Intramolecular Oxidoreductases - metabolism; Ionic interactions; Melanin; Melanins - biosynthesis; Melanocortin; Melanocyte-stimulating hormone; melanogenesis; Melanoma; Melanoma, Experimental - drug therapy; Melanoma, Experimental - metabolism; Mice; Microphthalmia-associated transcription factor; Microphthalmia-Associated Transcription Factor - metabolism; Molecular dynamics; Molecular Dynamics Simulation; Molecular weight; Monophenol Monooxygenase - antagonists & inhibitors; Monophenol Monooxygenase - metabolism; muscle tissues; muscles; Muscles - drug effects; Muscles - metabolism; mushrooms; Peptides; Phosphorylation; protein phosphorylation; Proteins; Receptor, Melanocortin, Type 1 - metabolism; Skin cancer; skin-whitening; Substrate inhibition; Synthesis; Takifugu - metabolism; Takifugu flavidus; Therapeutic targets; therapeutics; transcription factors; Tyrosinase; tyrosinase inhibitor; Variance analysis; Zebrafish; computational simulation; skin-whitening; tyrosinase inhibitor; Takifugu flavidus; inhibitory mechanism

Abnormal melanogenesis can lead to hyperpigmentation. Tyrosinase (TYR), a key rate-limiting enzyme in melanin production, is an important therapeutic target for these disorders. We investigated the TYR inhibitory activity of hydrolysates extracted from the muscle tissue of Takifugu flavidus (TFMH)....