Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

• Published in: The Journal of experimental medicine Vol. 216; no. 11; pp. 2562 - 2581
• Main Authors: Li, Sheng, Wu, Yuqing, Yang, Dongxue, Wu, Chunyan, Ma, Chunmei, Liu, Xue, Moynagh, Paul N., Wang, Bingwei, Hu, Gang, Yang, Shuo
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.11.2019

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in the CNS of EAE...