EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1 - Thomas, Shala L.; Zhong, Diansheng; Zhou, Wei; Malik, Sanna; Liotta, Dennis; Snyder, James P.; Hamel, Ernest; Giannakakou, Paraskevi (Cell cycle (Georgetown, Tex.), 2008)
Keywords: Antineoplastic Agents - pharmacology; Benzylidene Compounds - pharmacology; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cell Hypoxia - drug effects; Cell Hypoxia - genetics; Curcumin - analogs & derivatives; Curcumin - pharmacology; Cycle; Cytoskeleton - drug effects; Cytoskeleton - metabolism; Dose-Response Relationship, Drug; Down-Regulation - drug effects; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm - drug effects; Epothilones - therapeutic use; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Landes; Microtubules - drug effects; Microtubules - metabolism; Mitosis - drug effects; Neoplasms - pathology; Organogenesis; Paclitaxel - therapeutic use; Piperidones - pharmacology; Proteasome Endopeptidase Complex - drug effects; Proteasome Endopeptidase Complex - metabolism; Proteins; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein - metabolism