The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation

• Published in: Journal of virology Vol. 93; no. 23
• Main Authors: Wrapp, Daniel, McLellan, Jason S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.12.2019
• Subjects: Structure and Assembly; alphacoronavirus spike; PEDV; cryo-EM; S1-CTD

Coronavirus spike proteins are large, densely glycosylated macromolecular machines that mediate receptor binding and membrane fusion to facilitate entry into host cells. This report describes the atomic-resolution structure of the spike protein from porcine epidemic diarrhea virus, a pathogenic alph...