An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation

• Published in: Asian journal of pharmceutical sciences Vol. 18; no. 6; pp. 100869 - 143
• Main Authors: He, Wei, Fu, Daan, Gai, Yongkang, Liu, Xingxin, Yang, Chang, Ye, Zhilan, Chen, Xu, Liu, Jia, Chang, Bingcheng
• Format: Journal Article
• Language: English
• Published: Netherlands The Second Clinical College,The Second Affiliated Hospital,Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China%Department of Anesthesiology,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Nuclear Medicine,Hubei Province Key Laboratory of Molecular Imaging,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Laboratory Medicine,West China Second University Hospital,Sichuan University,Chengdu 610065,China%Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China%Department of Geriatrics,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Research Center for Tissue Engineering and Regenerative Medicine,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China 01.11.2023; Elsevier
• Subjects: Infectious microenvironments; Nanoscale drug delivery systems; Omiganan; Pathogens; Sepsis; Infectious microenvironments; Pathogens; Sepsis; Nanoscale drug delivery systems; Omiganan

Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise fo...