An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation
Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise fo...
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| Abstract | Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise for neutralizing endotoxins and eliminating diverse pathogens. However, its clinical application is hindered by safety and stability concerns. Herein, we present a nanoscale drug delivery system (Omi-hyd-Dex@HA NPs) that selectively targets infectious microenvironments (IMEs) and responds to specific stimuli for efficient intervention in sepsis. The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid (HA). The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes, but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase. The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation. In multiple tissue infection and sepsis animal models, Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction, thereby preventing subsequent fatal complications and significantly improving survival outcomes. The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies. |
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| AbstractList | Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation.Nevertheless,current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens.Omiganan,an antimicrobial peptide,has shown promise for neutralizing endotoxins and eliminating diverse pathogens.However,its clinical application is hindered by safety and stability concerns.Herein,we present a nanoscale drug delivery system(Omi-hyd-Dex@HA NPs)that selectively targets infectious microenvironments(IMEs)and responds to specific stimuli for efficient intervention in sepsis.The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid(HA).The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes,but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase.The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation.In multiple tissue infection and sepsis animal models,Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction,thereby preventing subsequent fatal complications and significantly improving survival outcomes.The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies. Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise for neutralizing endotoxins and eliminating diverse pathogens. However, its clinical application is hindered by safety and stability concerns. Herein, we present a nanoscale drug delivery system (Omi-hyd-Dex@HA NPs) that selectively targets infectious microenvironments (IMEs) and responds to specific stimuli for efficient intervention in sepsis. The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid (HA). The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes, but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase. The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation. In multiple tissue infection and sepsis animal models, Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction, thereby preventing subsequent fatal complications and significantly improving survival outcomes. The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies.Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise for neutralizing endotoxins and eliminating diverse pathogens. However, its clinical application is hindered by safety and stability concerns. Herein, we present a nanoscale drug delivery system (Omi-hyd-Dex@HA NPs) that selectively targets infectious microenvironments (IMEs) and responds to specific stimuli for efficient intervention in sepsis. The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid (HA). The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes, but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase. The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation. In multiple tissue infection and sepsis animal models, Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction, thereby preventing subsequent fatal complications and significantly improving survival outcomes. The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies. |
| ArticleNumber | 100869 |
| Author | Gai, Yongkang Chang, Bingcheng Liu, Xingxin Yang, Chang He, Wei Ye, Zhilan Liu, Jia Chen, Xu Fu, Daan |
| AuthorAffiliation | The Second Clinical College,The Second Affiliated Hospital,Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China%Department of Anesthesiology,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Nuclear Medicine,Hubei Province Key Laboratory of Molecular Imaging,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Laboratory Medicine,West China Second University Hospital,Sichuan University,Chengdu 610065,China%Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China%Department of Geriatrics,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Research Center for Tissue Engineering and Regenerative Medicine,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China |
| AuthorAffiliation_xml | – name: The Second Clinical College,The Second Affiliated Hospital,Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China%Department of Anesthesiology,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Nuclear Medicine,Hubei Province Key Laboratory of Molecular Imaging,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Department of Laboratory Medicine,West China Second University Hospital,Sichuan University,Chengdu 610065,China%Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China%Department of Geriatrics,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China%Research Center for Tissue Engineering and Regenerative Medicine,Tongji Medical College,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China |
| Author_xml | – sequence: 1 givenname: Wei surname: He fullname: He, Wei – sequence: 2 givenname: Daan surname: Fu fullname: Fu, Daan – sequence: 3 givenname: Yongkang surname: Gai fullname: Gai, Yongkang – sequence: 4 givenname: Xingxin surname: Liu fullname: Liu, Xingxin – sequence: 5 givenname: Chang surname: Yang fullname: Yang, Chang – sequence: 6 givenname: Zhilan surname: Ye fullname: Ye, Zhilan – sequence: 7 givenname: Xu surname: Chen fullname: Chen, Xu – sequence: 8 givenname: Jia surname: Liu fullname: Liu, Jia – sequence: 9 givenname: Bingcheng orcidid: 0000-0002-7405-8833 surname: Chang fullname: Chang, Bingcheng |
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| Cites_doi | 10.1016/j.jcis.2019.05.013 10.1001/jamasurg.2022.2761 10.1586/eri.12.50 10.1016/j.ajps.2021.03.001 10.1016/j.nantod.2021.101229 10.1016/S0140-6736(19)32989-7 10.1038/nrneph.2017.165 10.1021/acsnano.1c08913 10.1016/j.thromres.2013.07.002 10.3390/pharmaceutics12100931 10.1002/adma.201803618 10.1038/nprot.2008.214 10.1016/S1357-2725(97)00058-7 10.1002/smll.201601729 10.1016/j.ijpharm.2022.122045 10.1073/pnas.1714267114 10.1016/j.disamonth.2003.12.003 10.1016/j.jinf.2021.03.003 10.3390/ijms20215376 10.1007/s00134-016-4577-z 10.1186/s13054-021-03787-z 10.1016/j.biotechadv.2022.107962 10.1016/S0140-6736(18)30696-2 10.1007/s12602-021-09757-9 10.1186/s13054-017-1659-4 10.1016/j.addr.2022.114502 10.3389/fphar.2015.00249 10.1001/jama.2016.0287 10.1136/bmj.k3284 10.1021/acsnano.9b05608 10.1128/AAC.43.4.912 10.1073/pnas.2101721118 10.1126/science.aaa8334 10.3390/ijms22168882 10.24272/j.issn.2095-8137.2019.062 10.1186/s13054-016-1320-7 10.4155/tde-2018-0009 10.1128/AAC.48.8.3112-3118.2004 10.1007/BF00202069 10.1016/j.ajps.2022.05.002 10.1021/acsami.9b04051 10.1016/j.ajps.2022.10.003 10.3390/app112210695 10.1016/j.colsurfb.2006.06.007 10.1016/j.biomaterials.2021.121084 10.1007/s00134-021-06506-y 10.1016/S1473-3099(20)30327-3 10.3390/ijms222111401 10.1126/sciadv.abj1577 10.1016/j.ajps.2022.04.002 10.1017/ice.2019.74 10.1016/j.jconrel.2011.09.084 10.1038/nnano.2013.54 10.1016/j.chest.2019.01.013 10.1073/pnas.1106634108 10.1016/j.it.2012.09.004 |
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| Keywords | Infectious microenvironments Pathogens Sepsis Nanoscale drug delivery systems Omiganan |
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| References | Rao (10.1016/j.ajps.2023.100869_bib0041) 2020; 12 Wang (10.1016/j.ajps.2023.100869_bib0047) 2019; 13 Pickens (10.1016/j.ajps.2023.100869_bib0011) 2019; 156 Huang (10.1016/j.ajps.2023.100869_bib0028) 2019; 20 Ji (10.1016/j.ajps.2023.100869_bib0045) 2016; 12 Nazli (10.1016/j.ajps.2023.100869_bib0020) 2022; 189 Thamphiwatana (10.1016/j.ajps.2023.100869_bib0050) 2017; 114 Perner (10.1016/j.ajps.2023.100869_bib0010) 2016; 42 Martin (10.1016/j.ajps.2023.100869_bib0054) 2012; 10 Qin (10.1016/j.ajps.2023.100869_bib0058) 2021; 16 Zhang (10.1016/j.ajps.2023.100869_bib0025) 2018; 30 Reitz (10.1016/j.ajps.2023.100869_bib0004) 2022; 157 Luo (10.1016/j.ajps.2023.100869_bib0032) 2021; 22 Gibbison (10.1016/j.ajps.2023.100869_bib0019) 2017; 21 Lamontagne (10.1016/j.ajps.2023.100869_bib0006) 2018; 362 Yuk (10.1016/j.ajps.2023.100869_bib0005) 2018; 9 Javia (10.1016/j.ajps.2023.100869_bib0040) 2022; 624 Cecconi (10.1016/j.ajps.2023.100869_bib0001) 2018; 392 Le (10.1016/j.ajps.2023.100869_bib0024) 2021; 11 Hotchkiss (10.1016/j.ajps.2023.100869_bib0002) 2015; 347 Magana (10.1016/j.ajps.2023.100869_bib0033) 2020; 20 Vattimo Mde (10.1016/j.ajps.2023.100869_bib0048) 2016; 11 Wang (10.1016/j.ajps.2023.100869_bib0037) 2019; 552 Moriyama (10.1016/j.ajps.2023.100869_bib0014) 2021; 22 Chiotos (10.1016/j.ajps.2023.100869_bib0013) 2019; 40 Kollef (10.1016/j.ajps.2023.100869_bib0007) 2021; 25 Liu (10.1016/j.ajps.2023.100869_bib0057) 2022; 17 McCourt (10.1016/j.ajps.2023.100869_bib0043) 1997; 29 Singer (10.1016/j.ajps.2023.100869_bib0052) 2016; 315 Balk (10.1016/j.ajps.2023.100869_bib0008) 2004; 50 Rittirsch (10.1016/j.ajps.2023.100869_bib0053) 2009; 4 Chen (10.1016/j.ajps.2023.100869_bib0035) 2022; 16 Yuk (10.1016/j.ajps.2023.100869_bib0027) 2021; 7 Lai (10.1016/j.ajps.2023.100869_bib0038) 2022; 59 Bosmann (10.1016/j.ajps.2023.100869_bib0016) 2013; 34 Norpi (10.1016/j.ajps.2023.100869_bib0056) 2022; 17 Annane (10.1016/j.ajps.2023.100869_bib0018) 2015; 2015 Schromm (10.1016/j.ajps.2023.100869_bib0034) 2021; 118 Evans (10.1016/j.ajps.2023.100869_bib0055) 2021; 47 Rudd (10.1016/j.ajps.2023.100869_bib0003) 2020; 395 Zhang (10.1016/j.ajps.2023.100869_bib0021) 2019; 11 David (10.1016/j.ajps.2023.100869_bib0036) 1999; 43 Venet (10.1016/j.ajps.2023.100869_bib0015) 2018; 14 Jubeli (10.1016/j.ajps.2023.100869_bib0051) 2012; 158 Mwangi (10.1016/j.ajps.2023.100869_bib0031) 2019; 40 Liu (10.1016/j.ajps.2023.100869_bib0044) 2019; 6 Czechowicz (10.1016/j.ajps.2023.100869_bib0030) 2021; 13 Karam (10.1016/j.ajps.2023.100869_bib0012) 2016; 20 Hu (10.1016/j.ajps.2023.100869_bib0022) 2013; 8 Tan (10.1016/j.ajps.2023.100869_bib0039) 2021; 39 Asner (10.1016/j.ajps.2023.100869_bib0009) 2021; 82 Sader (10.1016/j.ajps.2023.100869_bib0029) 2004; 48 van de Stolpe (10.1016/j.ajps.2023.100869_bib0042) 1996; 74 Liu (10.1016/j.ajps.2023.100869_bib0046) 2021; 277 Akinosoglou (10.1016/j.ajps.2023.100869_bib0017) 2014; 133 Fan (10.1016/j.ajps.2023.100869_bib0026) 2015; 6 Hu (10.1016/j.ajps.2023.100869_bib0023) 2011; 108 Shao (10.1016/j.ajps.2023.100869_bib0059) 2022; 17 Bergstrand (10.1016/j.ajps.2023.100869_bib0049) 2006; 53 |
| References_xml | – volume: 552 start-page: 540 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0037 article-title: Understanding lipopolysaccharide aggregation and its influence on activation of factor c publication-title: J Colloid Interface Sci doi: 10.1016/j.jcis.2019.05.013 – volume: 157 start-page: 817 issue: 9 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0004 article-title: Association between time to source control in sepsis and 90-day mortality publication-title: JAMA Surg doi: 10.1001/jamasurg.2022.2761 – volume: 10 start-page: 701 issue: 6 year: 2012 ident: 10.1016/j.ajps.2023.100869_bib0054 article-title: Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes publication-title: Expert Rev Anti Infect Ther doi: 10.1586/eri.12.50 – volume: 16 start-page: 483 issue: 4 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0058 article-title: Targeting the resolution pathway of inflammation using Ac2-26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis publication-title: Asian J Pharm Sci doi: 10.1016/j.ajps.2021.03.001 – volume: 39 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0039 article-title: Design, optimization, and nanotechnology of antimicrobial peptides: from exploration to applications publication-title: Nano Today doi: 10.1016/j.nantod.2021.101229 – volume: 395 start-page: 200 issue: 10219 year: 2020 ident: 10.1016/j.ajps.2023.100869_bib0003 article-title: Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study publication-title: Lancet doi: 10.1016/S0140-6736(19)32989-7 – volume: 14 start-page: 121 issue: 2 year: 2018 ident: 10.1016/j.ajps.2023.100869_bib0015 article-title: Advances in the understanding and treatment of sepsis-induced immunosuppression publication-title: Nat Rev Nephrol doi: 10.1038/nrneph.2017.165 – volume: 16 start-page: 2429 issue: 2 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0035 article-title: Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis publication-title: ACS Nano doi: 10.1021/acsnano.1c08913 – volume: 133 start-page: 131 issue: 2 year: 2014 ident: 10.1016/j.ajps.2023.100869_bib0017 article-title: Use of antiplatelet agents in sepsis: a glimpse into the future publication-title: Thromb Res doi: 10.1016/j.thromres.2013.07.002 – volume: 12 start-page: 931 issue: 10 year: 2020 ident: 10.1016/j.ajps.2023.100869_bib0041 article-title: Hyaluronic acid nanoparticles as nanomedicine for treatment of inflammatory diseases publication-title: Pharmaceutics doi: 10.3390/pharmaceutics12100931 – volume: 30 issue: 43 year: 2018 ident: 10.1016/j.ajps.2023.100869_bib0025 article-title: Bioresponsive nanoparticles targeted to infectious microenvironments for sepsis management publication-title: Adv Mater doi: 10.1002/adma.201803618 – volume: 4 start-page: 31 issue: 1 year: 2009 ident: 10.1016/j.ajps.2023.100869_bib0053 article-title: Immunodesign of experimental sepsis by cecal ligation and puncture publication-title: Nat Protoc doi: 10.1038/nprot.2008.214 – volume: 2015 issue: 12 year: 2015 ident: 10.1016/j.ajps.2023.100869_bib0018 article-title: Corticosteroids for treating sepsis publication-title: Cochrane Database Syst Rev – volume: 29 start-page: 1179 issue: 10 year: 1997 ident: 10.1016/j.ajps.2023.100869_bib0043 article-title: On the adsorption of hyaluronan and icam-1 to modified hydrophobic resins publication-title: Int J Biochem Cell Biol doi: 10.1016/S1357-2725(97)00058-7 – volume: 12 start-page: 6200 issue: 45 year: 2016 ident: 10.1016/j.ajps.2023.100869_bib0045 article-title: Bacterial hyaluronidase self-triggered prodrug release for chemo-photothermal synergistic treatment of bacterial infection publication-title: Small doi: 10.1002/smll.201601729 – volume: 624 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0040 article-title: Liposomes encapsulating novel antimicrobial peptide omiganan: characterization and its pharmacodynamic evaluation in atopic dermatitis and psoriasis mice model publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2022.122045 – volume: 114 start-page: 11488 issue: 43 year: 2017 ident: 10.1016/j.ajps.2023.100869_bib0050 article-title: Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1714267114 – volume: 50 start-page: 168 issue: 4 year: 2004 ident: 10.1016/j.ajps.2023.100869_bib0008 article-title: Optimum treatment of severe sepsis and septic shock: evidence in support of the recommendations publication-title: Dis a Mon doi: 10.1016/j.disamonth.2003.12.003 – volume: 82 start-page: 125 issue: 5 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0009 article-title: Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock publication-title: J Infect doi: 10.1016/j.jinf.2021.03.003 – volume: 20 start-page: 5376 issue: 21 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0028 article-title: The pathogenesis of sepsis and potential therapeutic targets publication-title: IntJ Mol Sci doi: 10.3390/ijms20215376 – volume: 42 start-page: 1958 issue: 12 year: 2016 ident: 10.1016/j.ajps.2023.100869_bib0010 article-title: Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy publication-title: Intensive Care Med doi: 10.1007/s00134-016-4577-z – volume: 25 start-page: 360 issue: 1 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0007 article-title: Timing of antibiotic therapy in the ICU publication-title: Crit Care doi: 10.1186/s13054-021-03787-z – volume: 59 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0038 article-title: Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2022.107962 – volume: 392 start-page: 75 issue: 10141 year: 2018 ident: 10.1016/j.ajps.2023.100869_bib0001 article-title: Sepsis and septic shock publication-title: Lancet doi: 10.1016/S0140-6736(18)30696-2 – volume: 13 start-page: 1173 issue: 4 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0030 article-title: Anticandidal activity of omiganan and its retro analog alone and in combination with fluconazole publication-title: Probiotics Antimicrob Proteins doi: 10.1007/s12602-021-09757-9 – volume: 21 year: 2017 ident: 10.1016/j.ajps.2023.100869_bib0019 article-title: Corticosteroids in septic shock: a systematic review and network meta-analysis publication-title: Critical Care doi: 10.1186/s13054-017-1659-4 – volume: 189 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0020 article-title: Strategies and progresses for enhancing targeted antibiotic delivery publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2022.114502 – volume: 6 start-page: 249 year: 2015 ident: 10.1016/j.ajps.2023.100869_bib0026 article-title: S-thanatin functionalized liposome potentially targeting on klebsiella pneumoniae and its application in sepsis mouse model publication-title: Front Pharmacol doi: 10.3389/fphar.2015.00249 – volume: 315 start-page: 801 issue: 8 year: 2016 ident: 10.1016/j.ajps.2023.100869_bib0052 article-title: The third international consensus definitions for sepsis and septic shock (sepsis-3) publication-title: JAMA doi: 10.1001/jama.2016.0287 – volume: 362 start-page: k3284 year: 2018 ident: 10.1016/j.ajps.2023.100869_bib0006 article-title: Corticosteroid therapy for sepsis: a clinical practice guideline publication-title: BMJ doi: 10.1136/bmj.k3284 – volume: 13 start-page: 11686 issue: 10 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0047 article-title: Ph-switchable antimicrobial nanofiber networks of hydrogel eradicate biofilm and rescue stalled healing in chronic wounds publication-title: ACS Nano doi: 10.1021/acsnano.9b05608 – volume: 43 start-page: 912 issue: 4 year: 1999 ident: 10.1016/j.ajps.2023.100869_bib0036 article-title: Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.43.4.912 – volume: 118 issue: 27 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0034 article-title: Cathelicidin and pmb neutralize endotoxins by multifactorial mechanisms including lps interaction and targeting of host cell membranes publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.2101721118 – volume: 347 start-page: 1201 issue: 6227 year: 2015 ident: 10.1016/j.ajps.2023.100869_bib0002 article-title: Getting sepsis therapy right publication-title: Science doi: 10.1126/science.aaa8334 – volume: 11 issue: 8 year: 2016 ident: 10.1016/j.ajps.2023.100869_bib0048 article-title: Polymyxin b nephrotoxicity: from organ to cell damage publication-title: PLoS One – volume: 6 issue: 7 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0044 article-title: Redox-responsive dual drug delivery nanosystem suppresses cancer repopulation by abrogating doxorubicin-promoted cancer stemness, metastasis, and drug resistance publication-title: Adv Sci – volume: 22 start-page: 8882 issue: 16 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0014 article-title: Targeting cytokines, pathogen-associated molecular patterns, and damage-associated molecular patterns in sepsis via blood purification publication-title: Int J Mol Sci doi: 10.3390/ijms22168882 – volume: 40 start-page: 488 issue: 6 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0031 article-title: Antimicrobial peptides: new hope in the war against multidrug resistance publication-title: Zool Res doi: 10.24272/j.issn.2095-8137.2019.062 – volume: 20 start-page: 136 issue: 1 year: 2016 ident: 10.1016/j.ajps.2023.100869_bib0012 article-title: Antibiotic strategies in the era of multidrug resistance publication-title: Crit Care doi: 10.1186/s13054-016-1320-7 – volume: 9 start-page: 435 issue: 6 year: 2018 ident: 10.1016/j.ajps.2023.100869_bib0005 article-title: Recent advances in nanomedicine for sepsis treatment publication-title: Ther Deliv doi: 10.4155/tde-2018-0009 – volume: 48 start-page: 3112 issue: 8 year: 2004 ident: 10.1016/j.ajps.2023.100869_bib0029 article-title: Omiganan pentahydrochloride (mbi 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.48.8.3112-3118.2004 – volume: 74 start-page: 13 issue: 1 year: 1996 ident: 10.1016/j.ajps.2023.100869_bib0042 article-title: Intercellular adhesion molecule-1 publication-title: J Mol Med doi: 10.1007/BF00202069 – volume: 17 start-page: 523 issue: 4 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0057 article-title: Overcoming the cellular barriers and beyond: recent progress on cell penetrating peptide modified nanomedicine in combating physiological and pathological barriers publication-title: Asian J Pharm Sci doi: 10.1016/j.ajps.2022.05.002 – volume: 11 start-page: 16380 issue: 18 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0021 article-title: Ph-responsive nanoparticles targeted to lungs for improved therapy of acute lung inflammation/injury publication-title: ACS Appl Mater Interfaces doi: 10.1021/acsami.9b04051 – volume: 17 start-page: 855 issue: 6 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0059 article-title: Protein corona mediated liposomal drug delivery for bacterial infection management publication-title: Asian J Pharm Sci doi: 10.1016/j.ajps.2022.10.003 – volume: 11 start-page: 10695 issue: 22 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0024 article-title: Application of polymeric nanocarriers for enhancing the bioavailability of antibiotics at the target site and overcoming antimicrobial resistance publication-title: Appl Sci doi: 10.3390/app112210695 – volume: 53 start-page: 9 issue: 1 year: 2006 ident: 10.1016/j.ajps.2023.100869_bib0049 article-title: Aggregation behavior and size of lipopolysaccharide from escherichia coli o55:B5 publication-title: Colloids Surf B Biointerfaces doi: 10.1016/j.colsurfb.2006.06.007 – volume: 277 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0046 article-title: Multifunctional sgqds-corm@ha nanosheets for bacterial eradication through cascade-activated "nanoknife" effect and photodynamic/co gas therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2021.121084 – volume: 47 start-page: 1181 issue: 11 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0055 article-title: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 publication-title: Intensive Care Med doi: 10.1007/s00134-021-06506-y – volume: 20 issue: 9 year: 2020 ident: 10.1016/j.ajps.2023.100869_bib0033 article-title: The value of antimicrobial peptides in the age of resistance publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(20)30327-3 – volume: 22 start-page: 11401 issue: 21 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0032 article-title: Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities publication-title: Int J Mol Sci doi: 10.3390/ijms222111401 – volume: 7 start-page: eabj1577 issue: 32 year: 2021 ident: 10.1016/j.ajps.2023.100869_bib0027 article-title: Nanocapsules modify membrane interaction of polymyxin b to enable safe systemic therapy of gram-negative sepsis publication-title: Sci Adv doi: 10.1126/sciadv.abj1577 – volume: 17 start-page: 435 issue: 3 year: 2022 ident: 10.1016/j.ajps.2023.100869_bib0056 article-title: New modular platform based on multi-adjuvanted amphiphilic chitosan nanoparticles for efficient lipopeptide vaccine delivery against group A streptococcus publication-title: Asian J Pharm Sci doi: 10.1016/j.ajps.2022.04.002 – volume: 40 start-page: 693 issue: 6 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0013 article-title: Antibiotic stewardship in the intensive care unit: challenges and opportunities publication-title: Infect Control Hosp Epidemiol doi: 10.1017/ice.2019.74 – volume: 158 start-page: 194 issue: 2 year: 2012 ident: 10.1016/j.ajps.2023.100869_bib0051 article-title: E-selectin as a target for drug delivery and molecular imaging publication-title: J Control Release doi: 10.1016/j.jconrel.2011.09.084 – volume: 8 start-page: 336 issue: 5 year: 2013 ident: 10.1016/j.ajps.2023.100869_bib0022 article-title: A biomimetic nanosponge that absorbs pore-forming toxins publication-title: Nat Nanotechnol doi: 10.1038/nnano.2013.54 – volume: 156 start-page: 163 issue: 1 year: 2019 ident: 10.1016/j.ajps.2023.100869_bib0011 article-title: Principles and practice of antibiotic stewardship in the ICU publication-title: Chest doi: 10.1016/j.chest.2019.01.013 – volume: 108 start-page: 10980 issue: 27 year: 2011 ident: 10.1016/j.ajps.2023.100869_bib0023 article-title: Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1106634108 – volume: 34 start-page: 129 issue: 3 year: 2013 ident: 10.1016/j.ajps.2023.100869_bib0016 article-title: The inflammatory response in sepsis publication-title: Trends Immunol doi: 10.1016/j.it.2012.09.004 |
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| Title | An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation |
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