Distinct Contributions of Neutrophils and CCR2 + Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains

• Published in: Infection and immunity Vol. 83; no. 9; pp. 3418 - 3427
• Main Authors: Xiong, Huizhong, Carter, Rebecca A., Leiner, Ingrid M., Tang, Yi-Wei, Chen, Liang, Kreiswirth, Barry N., Pamer, Eric G.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2015
• Subjects: Animals; Bacterial Infections; Disease Models, Animal; Klebsiella Infections - immunology; Klebsiella Infections - microbiology; Klebsiella pneumoniae - immunology; Mice; Mice, Inbred C57BL; Monocytes - immunology; Neutrophils - immunology; Receptors, CCR2 - immunology; Respiratory Tract Infections - immunology; Respiratory Tract Infections - microbiology

Klebsiella pneumoniae is a common respiratory pathogen, with some strains having developed broad resistance to clinically available antibiotics. Humans can become infected with many different K. pneumoniae strains that vary in genetic background, antibiotic susceptibility, capsule composition, and m...