ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus

• Published in: Journal of virology Vol. 94; no. 6
• Main Authors: Yanai, Mako, Kojima, Shohei, Sakai, Madoka, Komorizono, Ryo, Tomonaga, Keizo, Makino, Akiko
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.02.2020
• Subjects: Virus-Cell Interactions; A-to-I editing; nuclear-replicating RNA virus; innate immunity; persistent infection; self/nonself

Cells use the editing activity of adenosine deaminase acting on RNA proteins (ADARs) to prevent autoimmune responses induced by self dsRNA, but viruses can exploit this process to their advantage. Borna disease virus (BoDV), a nuclear-replicating RNA virus, must escape nonself RNA sensing by the hos...