Normalization of the Vasculature for Treatment of Cancer and Other Diseases

• Published in: Physiological reviews Vol. 91; no. 3; pp. 1071 - 1121
• Main Authors: Goel, Shom, Duda, Dan G., Xu, Lei, Munn, Lance L., Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2011
• Subjects: Angiogenesis; Angiogenesis Inhibitors - therapeutic use; Animals; Blood Vessels - drug effects; Blood Vessels - pathology; Blood Vessels - physiopathology; Cancer; Disease; Disease Progression; Humans; Lymphatic System - physiopathology; Models, Cardiovascular; Neoplasms - blood supply; Neoplasms - pathology; Neoplasms - physiopathology; Neoplasms - therapy; Neovascularization, Pathologic - drug therapy; Pathology; Physiology; Rodents; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - antagonists & inhibitors

New vessel formation (angiogenesis) is an essential physiological process for embryologic development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the molecular level. Dysregulation of angiogenesis occurs in various pathologies and is one of the hallmarks of cancer. The im...