Scaling up of renewable chemicals
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| Published in | Current opinion in biotechnology Vol. 38; pp. 112 - 122 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.04.2016
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| Subjects | |
| Online Access | Get full text |
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| AbstractList | Graphical abstract The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As a result the timeframe estimated for commercialization is typically underestimated resulting in much slower penetration of these promising new methods and products into the chemical industries. The theme of 'sugar is the next oil' connects biological, chemical, and thermochemical conversions of renewable feedstocks to products that are drop-in replacements for petroleum derived chemicals or are new to market chemicals/materials. The latter typically offer a functionality advantage and can command higher prices that result in less severe scale-up challenges. However, for drop-in replacements, price is of paramount importance and competitive capital and operating expenditures are a prerequisite for success. Hence, scale-up of relevant technologies must be interfaced with effective and efficient management of both cell and steel factories. Details involved in all aspects of manufacturing, such as utilities, sterility, product recovery and purification, regulatory requirements, and emissions must be managed successfully. •Promising technologies for production of renewable chemicals have been developed.•Scale-up of renewable chemicals is expensive and time frame is often underestimated.•Synthetic biology and engineering are key to design/scale-up of biorefineries.•Strategic biomanufacturing of renewable chemicals will have major economic impact. The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As a result the timeframe estimated for commercialization is typically underestimated resulting in much slower penetration of these promising new methods and products into the chemical industries. The theme of ‘sugar is the next oil’ connects biological, chemical, and thermochemical conversions of renewable feedstocks to products that are drop-in replacements for petroleum derived chemicals or are new to market chemicals/materials. The latter typically offer a functionality advantage and can command higher prices that result in less severe scale-up challenges. However, for drop-in replacements, price is of paramount importance and competitive capital and operating expenditures are a prerequisite for success. Hence, scale-up of relevant technologies must be interfaced with effective and efficient management of both cell and steel factories. Details involved in all aspects of manufacturing, such as utilities, sterility, product recovery and purification, regulatory requirements, and emissions must be managed successfully. |
| Author | Sanford, Karl Chotani, Gopal Zahn, James A Danielson, Nathan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26874264$$D View this record in MEDLINE/PubMed |
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| Snippet | Graphical abstract •Promising technologies for production of renewable chemicals have been developed.•Scale-up of renewable chemicals is expensive and time frame is often... The transition of promising technologies for production of renewable chemicals from a laboratory scale to commercial scale is often difficult and expensive. As... |
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| Title | Scaling up of renewable chemicals |
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