Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

• Published in: The Journal of experimental medicine Vol. 216; no. 12; pp. 2883 - 2899
• Main Authors: Dai, Jinlu, Escara-Wilke, June, Keller, Jill M., Jung, Younghun, Taichman, Russell S., Pienta, Kenneth J., Keller, Evan T.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 02.12.2019
• Subjects: Animals; Bone Neoplasms - secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12 - genetics; Chemokine CXCL12 - metabolism; Disease Models, Animal; Exosomes - metabolism; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Male; Mice; Models, Biological; Prostatic Neoplasms - immunology; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; Stromal Cells - immunology; Stromal Cells - metabolism; Tumor Burden

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-derived exosomes promot...