Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis - Dai, Jinlu; Escara-Wilke, June; Keller, Jill M.; Jung, Younghun; Taichman, Russell S.; Pienta, Kenneth J.; Keller, Evan T. (The Journal of experimental medicine, 2019)
Keywords: Animals; Bone Neoplasms - secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12 - genetics; Chemokine CXCL12 - metabolism; Disease Models, Animal; Exosomes - metabolism; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Male; Mice; Models, Biological; Prostatic Neoplasms - immunology; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; Stromal Cells - immunology; Stromal Cells - metabolism; Tumor Burden