Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

• Published in: Molecular therapy. Nucleic acids Vol. 33; pp. 941 - 959
• Main Authors: Fitzsimons, Stephen, Muñoz-San Martín, María, Nally, Frances, Dillon, Eugene, Fashina, Ifeolutembi A., Strowitzki, Moritz J., Ramió-Torrentà, Lluís, Dowling, Jennifer K., De Santi, Chiara, McCoy, Claire E.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 12.09.2023; American Society of Gene & Cell Therapy; Elsevier
• Subjects: arginase-2; inflammation; macrophages; microRNA; miR-155; MT: Oligonucleotides: Therapies and Applications; multiple sclerosis; Original; target site blockers; MT: Oligonucleotides: Therapies and Applications; macrophages; inflammation; miR-155; multiple sclerosis; microRNA; target site blockers; arginase-2

The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response....