Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase

• Published in: Journal of virology Vol. 93; no. 18
• Main Authors: Broecker, Felix, Zheng, Allen, Suntronwong, Nungruthai, Sun, Weina, Bailey, Mark J, Krammer, Florian, Palese, Peter
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.09.2019
• Subjects: Spotlight; Vaccines and Antiviral Agents; influenza virus; vaccine; immunodominance; neuraminidase

Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). Anti-NA antibodies protect from lethal influenza virus challenge in the mouse model and correlate inversely with virus shedding and symptoms in humans. Consequently, the NA is a promising target f...