Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson's Disease
The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson's disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better und...
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Published in | Cells (Basel, Switzerland) Vol. 9; no. 2; p. 376 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Abstract | The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson's disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of
. Additionally, the abundance of
was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. |
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AbstractList | The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson’s disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of
Ruminococcaceae
. Additionally, the abundance of
Clostridiaceae
was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson's disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of Ruminococcaceae. Additionally, the abundance of Clostridiaceae was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson's disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of . Additionally, the abundance of was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. |
Author | Lebbing, Marco Duscha, Alexander Bjørn Nielsen, Henrik Tomaske, Laura Tönges, Lars Holm, Jacob Bak Przuntek, Horst Gatermann, Sören G Haghikia, Aiden Hegelmaier, Tobias |
AuthorAffiliation | 4 Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany; soeren.gatermann@rub.de 2 Clinic of Neurology II, EVK Hattingen, Hattingen 45525, Germany; marco.lebbing@googlemail.com (M.L.); przuntekh@t-online.de (H.P.) 3 Clinical Microbiomics A/S, Copenhagen 2200, Denmark; jacob@clinical-microbiomics.com (J.B.H.); hbjorn@clinical-microbiomics.com (H.B.N.) 1 Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany; tobias.hegelmaier@googlemail.com (T.H.); Alexander.Duscha@ruhr-uni-bochum.de (A.D.); Laura.Ackermann@ruhr-uni-bochum.de (L.T.); lars.toenges@rub.de (L.T.) |
AuthorAffiliation_xml | – name: 1 Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany; tobias.hegelmaier@googlemail.com (T.H.); Alexander.Duscha@ruhr-uni-bochum.de (A.D.); Laura.Ackermann@ruhr-uni-bochum.de (L.T.); lars.toenges@rub.de (L.T.) – name: 4 Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany; soeren.gatermann@rub.de – name: 3 Clinical Microbiomics A/S, Copenhagen 2200, Denmark; jacob@clinical-microbiomics.com (J.B.H.); hbjorn@clinical-microbiomics.com (H.B.N.) – name: 2 Clinic of Neurology II, EVK Hattingen, Hattingen 45525, Germany; marco.lebbing@googlemail.com (M.L.); przuntekh@t-online.de (H.P.) |
Author_xml | – sequence: 1 givenname: Tobias surname: Hegelmaier fullname: Hegelmaier, Tobias organization: Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany – sequence: 2 givenname: Marco surname: Lebbing fullname: Lebbing, Marco organization: Clinic of Neurology II, EVK Hattingen, Hattingen 45525, Germany – sequence: 3 givenname: Alexander surname: Duscha fullname: Duscha, Alexander organization: Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany – sequence: 4 givenname: Laura surname: Tomaske fullname: Tomaske, Laura organization: Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany – sequence: 5 givenname: Lars surname: Tönges fullname: Tönges, Lars organization: Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany – sequence: 6 givenname: Jacob Bak surname: Holm fullname: Holm, Jacob Bak organization: Clinical Microbiomics A/S, Copenhagen 2200, Denmark – sequence: 7 givenname: Henrik surname: Bjørn Nielsen fullname: Bjørn Nielsen, Henrik organization: Clinical Microbiomics A/S, Copenhagen 2200, Denmark – sequence: 8 givenname: Sören G surname: Gatermann fullname: Gatermann, Sören G organization: Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany – sequence: 9 givenname: Horst surname: Przuntek fullname: Przuntek, Horst organization: Clinic of Neurology II, EVK Hattingen, Hattingen 45525, Germany – sequence: 10 givenname: Aiden surname: Haghikia fullname: Haghikia, Aiden organization: Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, Germany |
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Keywords | vegetarian diet butyric acid enema microbiome Parkinson’s disease |
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SubjectTerms | Bacteria - drug effects butyric acid Case-Control Studies Cathartics - pharmacology Diet enema Female Gastrointestinal Microbiome - drug effects Humans Levodopa - pharmacology Levodopa - therapeutic use Male microbiome Middle Aged Motor Activity - drug effects Parkinson Disease - drug therapy Parkinson Disease - microbiology Parkinson Disease - physiopathology parkinson’s disease Phylogeny Principal Component Analysis vegetarian diet |
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Title | Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson's Disease |
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