Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

• Published in: The Journal of experimental medicine Vol. 220; no. 5
• Main Authors: Nickerson, Kevin M., Smita, Shuchi, Hoehn, Kenneth B., Marinov, Anthony D., Thomas, Kayla B., Kos, Justin T., Yang, Yi, Bastacky, Sheldon I., Watson, Corey T., Kleinstein, Steven H., Shlomchik, Mark J.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.05.2023
• Subjects: Animals; Autoimmunity; B-Lymphocyte Subsets; B-Lymphocytes; Lupus Erythematosus, Systemic - metabolism; Mice; Mice, Inbred MRL lpr

Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated with disease, and they are thought to be the source of autoantibody-secreting cells. However, in infl...