Therapeutics-how to treat phase separation-associated diseases

• Published in: Emerging topics in life sciences Vol. 4; no. 3; p. 307
• Main Author: Wheeler, Richard John
• Format: Journal Article
• Language: English
• Published: England 11.12.2020
• Subjects: neurodegeneration; drug discovery and design; therapeutics; cancer; condensates; liquid–liquid phase separation

Liquid-liquid phase separation has drawn attention as many neurodegeneration or cancer-associated proteins are able to form liquid membraneless compartments (condensates) by liquid-liquid phase separation. Furthermore, there is rapidly growing evidence that disease-associated mutation or post-transl...