Direct Interaction between Calmodulin and the Grb7 RA-PH Domain

• Published in: International journal of molecular sciences Vol. 21; no. 4; p. 1336
• Main Authors: Watson, Gabrielle M., Wilce, Jacqueline A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 17.02.2020
• Subjects: Calmodulin - genetics; Calmodulin - metabolism; Cell Movement; Cell Proliferation; Escherichia coli - genetics; Escherichia coli - metabolism; GRB7 Adaptor Protein - genetics; GRB7 Adaptor Protein - metabolism; Pleckstrin Homology Domains - genetics; Protein Binding; Protein Conformation; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; src Homology Domains - genetics; Surface Plasmon Resonance; Grb7; SH2 domain; SPR; RA-PH domain; Calmodulin

Grb7 is a signalling adapter protein that engages activated receptor tyrosine kinases at cellular membranes to effect downstream pathways of cell migration, proliferation and survival. Grb7’s cellular location was shown to be regulated by the small calcium binding protein calmodulin (CaM). While evi...