Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

• Published in: The Journal of experimental medicine Vol. 217; no. 12
• Main Authors: Zhang, Yu, Chandra, Vidhi, Riquelme Sanchez, Erick, Dutta, Prasanta, Quesada, Pompeyo R., Rakoski, Amanda, Zoltan, Michelle, Arora, Nivedita, Baydogan, Seyda, Horne, William, Burks, Jared, Xu, Hanwen, Hussain, Perwez, Wang, Huamin, Gupta, Sonal, Maitra, Anirban, Bailey, Jennifer M., Moghaddam, Seyed J., Banerjee, Sulagna, Sahin, Ismet, Bhattacharya, Pratip, McAllister, Florencia
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 07.12.2020
• Subjects: Animals; Biomarkers, Tumor - metabolism; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell Line, Tumor; Drug Resistance, Neoplasm - drug effects; Extracellular Traps - metabolism; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunosuppression; Innate immunity and inflammation; Interleukin-17 - pharmacology; Lymphocyte Activation - drug effects; Mice, Inbred C57BL; Neutrophils - drug effects; Neutrophils - pathology; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Programmed Cell Death 1 Receptor - metabolism; Signal Transduction - drug effects; Solid Tumors; Tumor immunology; Tumor Microenvironment - drug effects
• ISSN: 0022-1007; 1540-9538; 1540-9538
• DOI: 10.1084/jem.20190354

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive PDAC is undetermined. We hypothesized that IL17 triggers and sustains PDAC immuno...