The Structural Interface between HIV-1 Vif and Human APOBEC3H

• Published in: Journal of virology Vol. 91; no. 5
• Main Authors: Ooms, Marcel, Letko, Michael, Simon, Viviana
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2017
• Subjects: Aminohydrolases - chemistry; Base Sequence; Binding Sites; HEK293 Cells; HIV-1 - physiology; Humans; Molecular Docking Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Sequence Analysis, DNA; vif Gene Products, Human Immunodeficiency Virus - chemistry; Virus Replication; Virus-Cell Interactions; HIV-1; APOBEC3; Vif; HIV; APOBEC3H; A3H; restriction factor

Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication. To evade this restriction, the HIV-1 Vif protein binds A3H and mediates its proteasomal degradation. To date, little information on the Vif-A3H interface has been available. To decipher how both proteins interact, we first...