Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro

• Published in: International journal of molecular sciences Vol. 22; no. 6; p. 3163
• Main Authors: Ohashi, Hirofumi, Wang, Feng, Stappenbeck, Frank, Tsuchimoto, Kana, Kobayashi, Chisa, Saso, Wakana, Kataoka, Michiyo, Yamasaki, Masako, Kuramochi, Kouji, Muramatsu, Masamichi, Suzuki, Tadaki, Sureau, Camille, Takeda, Makoto, Wakita, Takaji, Parhami, Farhad, Watashi, Koichi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 19.03.2021
• Subjects: Administration, Oral; Animals; Antiviral Agents - administration & dosage; Antiviral Agents - chemistry; Antiviral Agents - pharmacokinetics; Antiviral Agents - pharmacology; Cell Survival - drug effects; Chlorocebus aethiops; COVID-19 - drug therapy; Mice; Nucleocapsid Proteins - drug effects; Oxysterols - administration & dosage; Oxysterols - chemistry; Oxysterols - pharmacokinetics; Oxysterols - pharmacology; SARS-CoV-2 - drug effects; SARS-CoV-2 - genetics; Vero Cells; Viral Replication Compartments - drug effects; Virus Replication - drug effects; COVID-19; replication; SARS-CoV-2; double membrane vesicle; oxysterols; antiviral; pharmacokinetics; coronavirus

The development of effective antiviral drugs targeting the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is urgently needed to combat the coronavirus disease 2019 (COVID-19). We have previously studied the use of semi-synthetic derivatives of oxysterols, oxidized derivatives o...