Fatty acids promote M1 polarization of monocyte-derived macrophages in healthy or ketotic dairy cows and a bovine macrophage cell line by impairing mTOR-mediated autophagy

• Published in: Journal of dairy science Vol. 107; no. 9; pp. 7423 - 7434
• Main Authors: Sun, Xudong, Gao, Shuang, Chang, Renxu, Jia, Hongdou, Xu, Qiushi, Mauck, John, Loor, Juan J., Li, Xiaobing, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2024; Elsevier
• Subjects: Animals; autophagy; Autophagy - drug effects; Cattle; Cell Line; dairy cow; Fatty Acids - metabolism; Fatty Acids - pharmacology; Female; ketosis; Ketosis - veterinary; Lipopolysaccharides - pharmacology; macrophage; Macrophages - drug effects; polarization; TOR Serine-Threonine Kinases - metabolism; macrophage; polarization; dairy cow; ketosis; autophagy

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Excessive concentrations of free fatty acids (FFA) are the main factors causing immune dysfunction and inflammation in dairy cows with ketosis. Polarization...