Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase
Novel myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus. Based upon observations from our initial findings, additional myxopyronin B analogs have been...
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| Published in | Bioorganic & medicinal chemistry letters Vol. 17; no. 24; pp. 6797 - 6800 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
15.12.2007
Elsevier |
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| Abstract | Novel myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against
Escherichia coli and
Staphylococcus aureus.
Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against
Escherichia coli and
Staphylococcus aureus. |
|---|---|
| AbstractList | Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus. Novel myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus. Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus. |
| Author | Simonsen, Klaus B. Shah, Amit M. Aust, Robert M. Banh, Virginia N. Biller, William T. Lira, Ricardo Appleman, James R. Xiang, Alan X. Webber, Stephen E. Agrios, Konstantinos A. Sisson, Wes Steffy, Kevin R. Doundoulakis, Thomas Showalter, Richard E. |
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| Keywords | Ortholithiation Curtius rearrangement Antibacterial Antibiotics Myxopyronin B Enzyme Transferases Escherichia coli Enzyme inhibitor Lactone Organic carbamate DNA-directed RNA polymerase In vitro Nucleotidyltransferases Antibiotic Lithiation Structure activity relation Bacteria Micrococcales Micrococcaceae Antibacterial agent Chemical synthesis Staphylococcus aureus Enterobacteriaceae |
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| References | Cook, Ternai, Ghosh (bib6) 1987; 30 Skulnich, Johnson, Howe, Tomich, Chong, Watenpaugh, Janakiraman, Dolak, McGrath, Lynn, Horng, Hinshaw, Zipp, Ruwart, Schwende, Zhong, Padbury, Dalga, Shiou, Possert, Rush, Wilkonson, Howard, Toth, Williams, Kakuk, Cole, Zaya, Lovasz, Morris, Romines, Thaisrivomgs, Aristoff (bib5) 1995; 38 Johnson, Shanoff, Boezi, Hansen (bib19) 1968; 26 Irschik, Gerth, Höfle, Kohl, Reichenbach (bib2) 1983; 36 bib14 bib15 bib13 bib10 Kohl, Irschik, Reichenbach, Höfle, Kohl, Irschik, Reichenbach, Höfle, Jansen, Irschik, Reichenbach, Höfle (bib1) 1983 bib20 bib9 Hu, Schaus, Lam, Palfreyman, Wuonola, Gustafson, Panek (bib12) 1998; 63 bib8 Campbell, Korzheva, Mustaev, Murakami, Nair, Goldfarb, Darst, Artsimovitch, Chu, Lynch, Landick (bib3) 2001; 104 Lira, Agrios, Doundoulakis, Simonsen, Webber, Xiang (bib11) 2006; 68 bib18 bib16 bib17 Kiang, Tan, Wong, Castillo, Ouadahi, Herault (bib7) 1971; 2 Doundoulakis, Xiang, Lira, Agrios, Webber, Sisson, Aust, Shah, Showalter, Appleman, Simonsen (bib4) 2004; 14 Cook (10.1016/j.bmcl.2007.10.017_bib6) 1987; 30 Hu (10.1016/j.bmcl.2007.10.017_bib12) 1998; 63 Skulnich (10.1016/j.bmcl.2007.10.017_bib5) 1995; 38 Johnson (10.1016/j.bmcl.2007.10.017_bib19) 1968; 26 Artsimovitch (10.1016/j.bmcl.2007.10.017_bib3_2) 2003; 302 Lira (10.1016/j.bmcl.2007.10.017_bib11) 2006; 68 Doundoulakis (10.1016/j.bmcl.2007.10.017_bib4) 2004; 14 Kiang (10.1016/j.bmcl.2007.10.017_bib7_1) 1971 Castillo (10.1016/j.bmcl.2007.10.017_bib7_2) 1982; 2 Jansen (10.1016/j.bmcl.2007.10.017_bib1_3) 1985 Kohl (10.1016/j.bmcl.2007.10.017_bib1_1) 1983 Kohl (10.1016/j.bmcl.2007.10.017_bib1_2) 1984 Irschik (10.1016/j.bmcl.2007.10.017_bib2) 1983; 36 Campbell (10.1016/j.bmcl.2007.10.017_bib3_1) 2001; 104 |
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| SubjectTerms | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Curtius rearrangement DNA-Directed RNA Polymerases - antagonists & inhibitors DNA-Directed RNA Polymerases - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Escherichia coli - drug effects Escherichia coli - enzymology Inhibitory Concentration 50 Lactones - chemical synthesis Lactones - chemistry Lactones - pharmacology Medical sciences Methylation Molecular Structure Myxopyronin B Ortholithiation Pharmacology. Drug treatments Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology |
| Title | Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase |
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