Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

• Published in: The Journal of experimental medicine Vol. 217; no. 7
• Main Authors: Toboso-Navasa, Amparo, Gunawan, Arief, Morlino, Giulia, Nakagawa, Rinako, Taddei, Andrea, Damry, Djamil, Patel, Yash, Chakravarty, Probir, Janz, Martin, Kassiotis, George, Brink, Robert, Eilers, Martin, Calado, Dinis Pedro
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.07.2020
• Subjects: AICDA (Activation-Induced Cytidine Deaminase); Animals; B-Lymphocytes - cytology; B-Lymphocytes - metabolism; Cell Cycle - genetics; Cell Differentiation; Cell Proliferation - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cytidine Deaminase - metabolism; Germinal Center - cytology; Immunologic Memory; Mice, Knockout; Protein Binding; Protein Inhibitors of Activated STAT - metabolism; Proto-Oncogene Proteins c-myc - metabolism; Ubiquitin-Protein Ligases - metabolism; Up-Regulation - genetics

Memory B cells (MBCs) are key for protection from reinfection. However, it is mechanistically unclear how germinal center (GC) B cells differentiate into MBCs. MYC is transiently induced in cells fated for GC expansion and plasma cell (PC) formation, so-called positively selected GC B cells. We foun...