Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice

• Published in: Journal of virology Vol. 94; no. 6
• Main Authors: Imura, Ayumi, Sudaka, Yui, Takashino, Ayako, Tamura, Kanami, Kobayashi, Kyousuke, Nagata, Noriyo, Nishimura, Hidekazu, Mizuta, Katsumi, Koike, Satoshi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.02.2020
• Subjects: Animals; Cell Line; Disease Models, Animal; Drug Evaluation; Enterovirus A, Human - genetics; Enterovirus A, Human - immunology; Enterovirus A, Human - pathogenicity; Hand, Foot and Mouth Disease - genetics; Hand, Foot and Mouth Disease - immunology; Hand, Foot and Mouth Disease - pathology; Hand, Foot and Mouth Disease - prevention & control; Humans; Lysosomal Membrane Proteins - genetics; Lysosomal Membrane Proteins - immunology; Mice; Mice, Transgenic; Receptors, Scavenger - genetics; Receptors, Scavenger - immunology; Vaccines and Antiviral Agents; Vaccines, Inactivated - genetics; Vaccines, Inactivated - immunology; Vaccines, Inactivated - pharmacology; Viral Vaccines - genetics; Viral Vaccines - immunology; Viral Vaccines - pharmacology; enterovirus; vaccines; animal models

The development of new vaccines for EV71 relies on the availability of small animal models suitable for in vivo efficacy testing. Monkeys and neonatal mice have been used, but the use of these animals has several drawbacks, including high costs, limited susceptibility, and poor experimental reproduc...