A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model

• Published in: Pain (Amsterdam) Vol. 123; no. 1; pp. 28 - 36
• Main Authors: Staahl, Camilla, Christrup, Lona Louring, Andersen, Søren Due, Arendt-Nielsen, Lars, Drewes, Asbjørn Mohr
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2006; Elsevier
• Subjects: Adult; Analgesics; Analgesics, Opioid - therapeutic use; Biological and medical sciences; Cross-Over Studies; Dose-Response Relationship, Drug; Electroshock - adverse effects; Esophagus - innervation; Experimental pain; Female; Fundamental and applied biological sciences. Psychology; Hot Temperature - adverse effects; Humans; Illness and personality; Illness, stress and coping; Male; Medical sciences; Models, Neurological; Morphine; Morphine - therapeutic use; Muscle, Skeletal - innervation; Neuropharmacology; Nociceptors - drug effects; Organ Specificity; Oxycodone; Oxycodone - therapeutic use; Pain - drug therapy; Pain - etiology; Pain - physiopathology; Pain Measurement; Pain Threshold; Pharmacology. Drug treatments; Pressure - adverse effects; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Skin - innervation; Visceral pain; Experimental pain; Morphine; Visceral pain; Oxycodone; Animal model; Stimulus modality; Oral administration; Analgesic; Pain; Treatment; Modulation; Placebo; Skin; Comparative study

Visceral pain can be difficult to treat with classical μ-opioid agonists and it has been suggested to use opioids with distinct pharmacological profiles. In animal experiments, oxycodone has shown different effects compared to morphine, and clinical observations have shown that oxycodone may occasio...