The induction of interferon by temperature-sensitive mutants of reovirus, UV-irradiated reovirus, and subviral reovirus particles

• Published in: Virology (New York, N.Y.) Vol. 51; no. 1; pp. 191 - 204
• Main Authors: Lai, Mei-Huei T., Joklik, Wolfgang K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 1973
• Subjects: Animals; Biological Assay; Centrifugation, Density Gradient; Clone Cells; Interferon Inducers; Interferons - analysis; Interferons - biosynthesis; L Cells (Cell Line); Mice; Mutation; Nucleoproteins; Radiation Effects; Recombination, Genetic; Reoviridae - growth & development; Reoviridae - metabolism; Reoviridae - radiation effects; RNA, Viral - biosynthesis; Temperature; Tritium; Ultraviolet Rays; Vesicular stomatitis Indiana virus; Viral Proteins - biosynthesis; Virus Replication

The ability of temperature-sensitive (ts) mutants of reovirus, UV-irradiated reovirus, and subviral particles of reovirus to induce interferon in mouse L929 fibroblasts was investigated. The following results were obtained: 1. 1. Nine ts mutants belonging to six recombination groups induced about th...