Associations of cardiometabolic multimorbidity with all-cause dementia, alzheimer’s disease, and vascular dementia: a cohort study in the UK biobank

• Published in: BMC public health Vol. 25; no. 1; pp. 2397 - 13
• Main Authors: Zhang, Junrun, Huang, Xiaxuan, Ling, Yitong, Xie, Xiaomei, Zeng, Xiuli, Lyu, Jun, Huang, Li’an
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.07.2025; BMC
• Subjects: Aged; Alzheimer Disease - epidemiology; Alzheimer's disease; Biobanks; Biological Specimen Banks; Biomarkers; Body mass index; Brain research; Cardiometabolic disease; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cholesterol; Cognitive ability; Cohort analysis; Cohort Studies; Comorbidity; Confidence intervals; Dementia; Dementia - epidemiology; Dementia disorders; Dementia, Vascular - epidemiology; Diabetes; Diabetes mellitus (non-insulin dependent); Education; Female; Glucose; Heart; Heart diseases; Hemoglobin; High density lipoprotein; Humans; Hypertension; Inflammation; Ischemia; Leukocytes; Leukocytes (neutrophilic); Lymphocytes; Male; Metabolism; Middle Aged; Mortality; Multimorbidity; Neurodegenerative diseases; Primary care; Prospective Studies; Regression analysis; Regression models; Sexually transmitted diseases; Statistical analysis; STD; Stroke; Subgroups; Triglycerides; UK Biobank; United Kingdom - epidemiology; Vascular dementia; United Kingdom; United Kingdom > UK; Cardiometabolic disease; Inflammation; Metabolism; Dementia

Cardiometabolic diseases (CMDs) including type 2 diabetes, heart disease, and stroke, increase the risk of dementia. However, the correlation between CMDs and dementia in different subgroups and the underlying pathophysiological mechanisms linking CMDs with dementia warrant further investigation. Th...