Effects of interleukin-2 in immunostimulation and immunosuppression

Historically, interleukin-2 (IL-2) was first described as an immunostimulatory factor that supports the expansion of activated effector T cells. A layer of sophistication arose when regulatory CD4+ T lymphocytes (Tregs) were shown to require IL-2 for their development, homeostasis, and immunosuppres...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 217; no. 1
Main Authors Pol, Jonathan G., Caudana, Pamela, Paillet, Juliette, Piaggio, Eliane, Kroemer, Guido
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 06.01.2020
SeriesCytokines Focus
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