Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer

• Published in: International journal of molecular sciences Vol. 21; no. 18; p. 6792
• Main Authors: Gurunathan, Sangiliyandi, Jeyaraj, Muniyandi, Kang, Min-Hee, Kim, Jin-Hoi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 16.09.2020; MDPI AG
• Subjects: anticancer activity; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antioxidants - metabolism; Apoptosis - drug effects; beta Carotene - pharmacology; Cell Differentiation - drug effects; Cell Division - drug effects; Cell Line, Tumor; Cisplatin - pharmacology; Crystallography, X-Ray; cytotoxicity; Drug Screening Assays, Antitumor; Drug Synergism; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Humans; L-Lactate Dehydrogenase - analysis; Membrane Potential, Mitochondrial - drug effects; Metal Nanoparticles - chemistry; Metal Nanoparticles - therapeutic use; Metal Nanoparticles - toxicity; Neoplasm Proteins - metabolism; Neuroblastoma - drug therapy; Neuroblastoma - pathology; oxidative stress; Oxidative Stress - drug effects; Peptide Hydrolases - analysis; Platinum - administration & dosage; Platinum - pharmacology; Platinum - toxicity; platinum nanoparticle; retinoic acid; Tretinoin - administration & dosage; Tretinoin - pharmacology; platinum nanoparticle; retinoic acid; apoptosis; anticancer activity; mitochondrial dysfunctions; cytotoxicity; endoplasmic reticulum stress; oxidative stress

Neuroblastoma is the most common extracranial solid tumor in childhood. The different treatments available for neuroblastoma are challenged by high rates of resistance, recurrence, and progression, most notably in advanced cases and highly malignant tumors. Therefore, the development of more targete...