Context-dependent EMT programs in cancer metastasis

• Published in: The Journal of experimental medicine Vol. 216; no. 5; pp. 1016 - 1026
• Main Authors: Aiello, Nicole M., Kang, Yibin
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.05.2019
• Subjects: Animals; Biomarkers, Tumor; Cell Movement; Cell Plasticity; Epithelial Cells - metabolism; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Mesenchymal Stem Cells - metabolism; Mice; Neoplasm Metastasis; Neoplasms - pathology; Reviews

Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary, adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements during embryogenesis; however, tumor cells can reactivate EMT programs, which increases their aggressiveness. In addit...