VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma

• Published in: Human cell : official journal of Human Cell Research Society Vol. 37; no. 4; pp. 1141 - 1155
• Main Authors: Miao, Huikai, Gao, Wuyou, Zhong, Leqi, Li, Hongmu, Chen, Dongni, Xu, Chunmei, Wen, Zhesheng, Chen, Youfang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.07.2024; Springer Nature B.V
• Subjects: Animals; Atrophy; Biomedical and Life Sciences; Cell Biology; Cell Line, Tumor; Cell Proliferation - genetics; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - metabolism; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Gene Expression - genetics; Gene Expression Regulation, Neoplastic - genetics; Genes; Gynecology; Homeostasis; Humans; Hypoxia; Hypoxia - genetics; Immunohistochemistry; Life Sciences; Metastases; Oncology; Prognosis; Reproductive Medicine; Research Article; Solid tumors; Squamous cell carcinoma; Stem Cells; Surgery; Transcriptome - genetics; Transcriptomes; Tumor Hypoxia - genetics; Tumor microenvironment; Esophageal squamous cell carcinoma; Hypoxia; Prognosis; Proliferation; VBP1

Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor in East Asia. Hypoxia, a hallmark of solid tumors, significantly alters redox homeostasis inside tumor microenvironment. This alteration drives tumor proliferation, invasion, and metastasis, leading to poor prognostic outcomes. Ho...