Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model - Wang, Shoutang; Mustafa, Meer; Yuede, Carla M.; Salazar, Santiago Viveros; Kong, Philip; Long, Hua; Ward, Michael; Siddiqui, Omer; Paul, Robert; Gilfillan, Susan; Ibrahim, Adiljan; Rhinn, Hervé; et al. (The Journal of experimental medicine, 2020)
Keywords: Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - pathology; Alzheimer Disease - therapy; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; Animals; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - pharmacokinetics; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Anxiety - pathology; Biomarkers - cerebrospinal fluid; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - pathology; Cell Proliferation - drug effects; Disease Models, Animal; Humans; Membrane Glycoproteins - immunology; Membrane Glycoproteins - metabolism; Mice, Inbred C57BL; Mice, Transgenic; Microglia - drug effects; Microglia - metabolism; Microglia - pathology; Neurites - drug effects; Neurites - pathology; Neuroinflammation; Osteopontin - metabolism; Protein Conformation; Receptors, Immunologic - immunology; Receptors, Immunologic - metabolism; Signal Transduction; Solubility