Transmitted antiretroviral drug resistance and thumb subdomain polymorphisms among newly HIV type 1 diagnosed patients infected with CRF01_AE and CRF07_BC virus in Guangdong Province, China

• Published in: AIDS research and human retroviruses Vol. 28; no. 12; p. 1723
• Main Authors: Yang, Changfu, Liu, Shuyuan, Zhang, Taisong, Hou, Yaping, Liu, Xiaoli, Gao, Yun, Yang, Guang, Wang, Zhen, Chen, Huayun, Li, Ming, Zhu, Zhenyu
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Adult; Anti-Retroviral Agents - pharmacology; China - epidemiology; Cluster Analysis; Drug Resistance, Viral; Female; Genotype; HIV Infections - transmission; HIV Infections - virology; HIV Protease - genetics; HIV Reverse Transcriptase - genetics; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - isolation & purification; Humans; Male; Middle Aged; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Analysis, DNA; China

The aim of this study was to elucidate the prevalence of transmitted drug-resistant (TDR) mutations and reverse transcriptase (RT) thumb subdomain polymorphisms in CRF01_AE and CRF07_BC virus among newly diagnosed, therapy-naive HIV-1 patients in Guangdong Province, China. One hundred and sixty-four...