Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2

• Published in: Journal of virology Vol. 94; no. 13
• Main Authors: Nguyen, Austin, David, Julianne K., Maden, Sean K., Wood, Mary A., Weeder, Benjamin R., Nellore, Abhinav, Thompson, Reid F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.06.2020
• Subjects: Amino Acid Sequence; Betacoronavirus - immunology; Clinical Laboratory Techniques; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronavirus Infections - virology; COVID-19; COVID-19 Testing; Epitopes, T-Lymphocyte - immunology; Genetic Diversity and Evolution; Genetic Variation; Genotype; Haplotypes; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; Histocompatibility Testing - methods; Humans; Immunity, Innate - immunology; Pandemics; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; SARS-CoV-2; T-Lymphocytes - immunology; COVID-19; MHC class I; coronavirus; SARS-CoV-2; HLA

Individual genetic variation may help to explain different immune responses to a virus across a population. In particular, understanding how variation in HLA may affect the course of COVID-19 could help identify individuals at higher risk from the disease. HLA typing can be fast and inexpensive. Pai...